发热伴血小板减少综合征(SFTS)是一种新发传染病,由新型的布尼亚病毒科白蛉病毒属病毒引起。SFTS进展期间出现脑炎/脑病被认为预后较差的主要因素。本文所述为一例危重病人出现SFTS相关的脑炎/脑病,表现为胼胝体压部病变,最终治愈。
Casepresentation
A56-year-oldJapaneseman,whohadbeenengagedinagriculturalactivitiesinahillyruralareaofJapan,presentedtoalocalhospitalinAugust,witha2-dayhistoryoffeveranddiarrhea.Dysarthriaandirritabilitywerealsoevident.Hehadlong-standingdiabetesmellitusthathadbeenwellcontrolledwithmetformin.Hisvitalsignswerenormalexceptforpyrexia(temperatureof38.5°C).
患者,男,56岁,农民。8月份曾因发烧和腹泻2医院治疗。构音障碍和易怒较明显。患者长期患有糖尿病,用药甲福明二甲双胍控制良好。除发热(体温38.5°C)外,其他生命体征正常。
Laboratorytestsdemonstratedleukopenia,thrombocytopenia,hyponatremia,andincreasedlevelsofaspartateaminotransferase(AST),alanineaminotransferase(ALT),lactatedehydrogenase(LDH),andcreatinekinase(CK).BrainMRIrevealedahyperintenselesionintheSCConT2-(Fig.1a)anddiffusion-weighted(DW)(Fig.1b)imagesequences.Apreliminarydiagnosisofcerebralinfarctionwasmade,andintravenousadministrationofedaravonewasstarted.However,hisclinicalconditionhadnotimprovedbythe3rddayafterillnessonset,andhewas,therefore,transferredtoourhospital.
医院时,患者实验室检查发现白细胞减少症、血小板减少症、低钠血症,天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、乳酸脱氢酶(LDH)和肌酸激酶(CK)水平升高。脑MRI显示SCCT2加权像呈高信号(图1a),弥散加权(DW)图像(图1b)。初步诊断为脑梗死,开始静脉注射依达拉奉。但是,症状发作3天后,患者临床症状未见缓解,因此转至我院。
图1:
Onadmission,ourpatient’sGlasgowscore(GCS)was12(E3,V3,M6),andheshowedlimbtremorandscanningspeech.Atickbitewoundwasobservedontheanterioraspectofhisrightankle.
入院时,患者格拉斯哥昏迷评分为12(E3,V3,M6),肢体震颤,断续言语。观察到右踝前侧面有一个被蜱虫叮咬的伤口。
Bloodtestsshowedleukopeniawithashifttotheleft,2.8×/L(normalrange:4.0–9.0)with1%ofatypicallymphocyte.
验血显示白细胞减少,左移,2.8×/L(正常范围:4.0–9.0),1%非典型淋巴细胞。
Theotherlaboratorytestsyieldedthefollowingresults:
plateletcount,59×/L(–);
andhemoglobin,14.7g/dL(12–16);
C-reactiveprotein,1.51mg/dL(0–0.3);
AST,U/L(13–33);
ALT,59U/L(8–42);
LDH,U/L(–);
creatinine,1.21mg/dL(0.36–1.06);
CK,U/L(62–);
serumferritin,U/mL(–);
andsodiumlevels,mmol/L(–).
Contrast-enhancedwhole-body北京哪里看白癜风比较好谁看好了白癜风