TeaserCurrenttuberculosis(TB)vaccineshavesomedisadvantagesandmanyeffortshavebeenundertakentoproduceeffectiveTBvaccines.Asaresultoftheiradvantages,DNAvaccinesarepromisingfuturevaccinecandidates.ThisreviewfocusesonthedesignanddeliveryofnovelDNA-basedvaccinesagainstTB.
译：目前的结核病疫苗有一些缺点，已经做出了许多努力来生产有效的结核病疫苗。由于它们的优势，DNA疫苗是未来很有希望的候选疫苗。本文综述了新型抗结核DNA疫苗的设计和交付情况
RecentprogressinthedesignofDNAvaccinesagainsttuberculosis
抗结核DNA疫苗设计的最新进展
作者：
1.AhadMokhtarzadeh——worksinthefifieldofpharmaceuticalbiotechnologyintheImmunologyResearchCenter,TabrizUniversityofMedicalSciences,Iran.Hismainresearchfocusisoncancertherapy,nanoparticle-baseddrug/genedeliverysystems,andthedevelopmentofbiosensorsfordetectionofdifferentanalytes.
AhadMokhtarzadeh--在伊朗大不里士医科大学免疫学研究中心的制药生物技术领域工作。他的主要研究重点是癌症治疗、基于纳米颗粒的药物/基因输送系统，以及用于检测不同分析物的生物传感器的开发。
2.Mohammad-AliShahbazi——receivedhisPhDinfromUniversityofHelsinki,Finland,whereheworkedonporousmaterialsfordrugdeliverytocancertissues.HeiscurrentlyapostdocscientistintheFacultyofPharmacy,UniversityofHelsinki,workingontherapeuticmicrodevicesforautoimmunediseases.Heisanexpertinoralpeptidedeliveryandfabricationofcell-mimickingcarriers.Hiscurrentresearchinterestliesinnano-basedregenerativehydrogelsforwoundhealing,bonerepair,andlong-termdrugdelivery.
Mohammad-AliShahbazi-年在芬兰赫尔辛基大学获得博士学位，在那里他致力于向癌症组织输送药物的多孔材料。他目前是赫尔辛基大学药学院的博士后科学家，致力于治疗自身免疫性疾病的微型设备。他是口服多肽递送和模拟细胞载体制造方面的专家。他目前的研究兴趣在于用于伤口愈合、骨修复和长期药物输送的纳米再生水凝胶。
3.H?lderA.Santos——obtainedhisPhD(chemicalengineering)infromtheHelsinkiUniversityofTechnology.Currently,heisafullprofessorinpharmaceuticalnanotechnologyintheFacultyofPharmacy,UniversityofHelsinki,andHeadoftheNanomedicinesandBiomedicalEngineeringresearchgroup.Hisscientifificexpertiseliesinthedevelopmentofnanoparticles/nanomedicinesforbiomedicalapplications,particularlyporoussiliconandpolymeric-basednanomaterials,forsimultaneouscontrolleddrugdelivery,diagnostic,andtherapyforcancer,diabetes,andcardiovasculardiseases.
HlderA.Santos--年在赫尔辛基理工大学获得化学工程博士学位。目前，他是赫尔辛基大学药学院药物纳米技术的全职教授，纳米医学和生物医学工程研究组组长。他的科学专长在于开发用于生物医学应用的纳米颗粒/纳米药物，特别是多孔硅和基于聚合物的纳米材料，用于同时控制癌症、糖尿病和心血管疾病的药物输送、诊断和治疗。
BacillusCalmette–Guerin(BCG)isanestablishedvaccineusedfortuberculosis(TB)prevention;however,itisnoteffectiveinadultsandisonlyprotectiveforchildren’sextrapulmonaryTB.Therefore,manyeffortshavefocusedonproducingeffectiveTBvaccinesforadults.OnepromisingapproachisDNAvaccinationbecauseofitsabilitytoelicitbothhumoralandcellularimmuneresponses,lowcost,rapidproduction,desirablestability,andeffificientprotectionagainstseveralinfectiousdiseases.Nanoparticle(NP)-basedsystemscanalsoenhancetheimmunogenicityofDNAvaccinesbyprotectingnakedplasmidDNAfromnucleasesandimprovingitsdeliverytoimmunecells.Inthisreview,wefocusonthedesignanddeliveryofnovelDNA-basedvaccinesagainstTBandsummarizeinvestigationsonspecifificmycobacterialantigensandchimeric
